university of utah mass spectrometry

First of all the lab has an Amnis Imagestream Imaging Flow Cytometer. The core is also equipped with a variety of liquid handling instruments (Tecan EVO 96-well and Tecan EVO 384-well automated liquid handling systems with sterile enclosure). The LCQ-Deca is an ion-trap mass spectrometer with electrospray (ESI) ionization and MS/MS or MSnth capabilities. The EM Core Lab is equipped for cryogenic TEM. The Mass Spectrometry and Proteomics Facilityparticipates occassionally in an international proteomics proficiency evaluation conducted by the Association of Biomolecular Resource Facilities (ABRF). We are currently staffed with 5 full time employees. The NMR facility owns substantial computing resources and has full membership in the SBGrid consortium. We also have a 5 laser Cytek Aurora Spectral Analyzer with 64 detectors. In fact, many researchers are utilizing both techniques in parallel, in which one tissue section is stained and another corresponding section is analyzed directly by mass spectrometry. The CZAR is approved and regularly inspected by the Institutional Animal Care and Use Committee (IACUC) and the University of Utah is fully accredited by the American Association for Accreditation of Laboratory Animal Care. MS/MS scan functions: Facilities and Instrumentation and Services: The Core employs a proven pipeline for metabolomics and lipidomics with the overarching theme of biomarker discovery using a non-biased discovery approach followed by validation using targeted quantitative mass spectrometry. The primary focus of the Facility is support of proteomics research at the University of Utah. University of Utah Metabolic Phenotyping Core (MPC) is a comprehensive resource that provides access to state-of-the-art instruments and experimental metabolic testing services. As part of the University Core Facilities, scans performed at the facility are assessed a nominal hourly chargeback fee.

The Genomics Core Facility also offers training and real time PCR instrument access for researches interested in performing gene expression studies ranging from single targets to hundreds of genes. Within the University of Utah, the National Center for Veterans Studies (NCVS) is charged with engaging in research in order to improve the lives of veterans, and is located in the Gardner Building on the south campus. Our shop handles all types of fabrication including welding of exotic materials, milling, drilling, lathe work, CNC controlled machines, plastic working equipment, and wood working tools. We are known for our ability to take an idea from concept to working drawings, then to working products in a short period of time. For applications of the UltrafleXtreme instrument, see available Services. The laboratory space housing these systems includes laboratory benches and cell culture and chemistry hoods. The Proteomics and Mass Spectrometry Core at the University of Utah is one of the longest serving cores at the University of Utah and provides proteomics and mass spectrometry services for the campus community, other academic institutions and biotech companies in the regional area. kathryn morton brain rsc metallomics icp plasma spectrometry ablation inductively bioimaging metals coupled tissue mass laser ms Information from tissue imaging can also be utilized in coordination with tissue sampling and proteomics by LC/MS/MS, now done routinely at the MS and Proteomics Core. As an integrated part of the Core Facilities Department, Fluorescence Microscopy can support current multidisciplinary research and facilitate the preliminary stages of new investigations. The TGTC utilizes the latest technology and strives to optimize the newest techniques to efficiently generate requested mice for researchers both on campus and throughout the world. An FEI Vitrobot vitrification robot is located in the Sorenson building. We attribute the success of our Core to the many years of expertise and vast knowledge of the highly qualified members of our team using our state of the art, highly sophisticated equipment. This instrument provides ultimate sensitivity and confidence in protein ID, in which proteins can be identified from a Mascot database search with as few as one or two peptides identified from attomole-level of digest injected on column. Lastly, the MGD core has specialized equpiment available for community use including a BioFire Defense LightScanner and a Lonza 4D Nucleofector. A ThermoFisher Tecnai F20 TEM (200kV) and a ThermoFisher Titan Krios TEM (300 kV) are located in the Crocker Science Center. (i.e. Professor Armentrout is a member of the editorial advisory boards of the Journal of the American Society of Mass Spectrometry and the International Journal of Mass Spectrometry and Ion Processes, and formerly of the Journal of the American Chemical Society, Journal of Physical Chemistry, Journal of Chemical Physics, Organometallics, and the Journal of Cluster Science (charter member). Metamorph, Nikon Elements, Imaris, Leica, and Zeiss Zen software are available for 2D and 3D analysis of image data. Data from standard DNA sequencing services are typically reported to customers same day in as little as 6 hours from receipt of the samples. He developed the guided ion beam threshold dissociation approach to provide insights into the thermochemistry, kinetics, and dynamics of simple and complex chemical reactions. CLAMS metabolic chambers are available for energy balance (food intake, energy expenditure and locomotor activity) at multiple ambient temperatures. Ultrasound has long been an extremely important tool in the practice of clinical medicine because it offers real-time imaging providing understanding of anatomy and physiology, is non-invasive and can be repeated serially. The University of Utah Mutation Generation & Detection (MGD) Core Facility supports researchers by developing and optimizing the latest DNA nuclease reagents and protocols for targeted genome editing. In addition to quantitative proteomics the Core also performs PTM analysis on digested peptides using various enrichment strategies. The UltrafleXtreme is a high-performance instrument well suited for a wide range of applications, including polymers, proteins, peptides, carbohydrates, and other biomolecules. The uniqueness of the Drug Discovery Core is that it coordinates the cooperative efforts of individual research groups in a wide variety of different drug discovery stuides, ultimately leading to discover novel chemical probes and new pharmaceutical lead compounds. The MGD core provides training of lab personnel in the use of this equipment, the implementation of the DNA nuclease reagents and help in troubleshooting problems should they arise. The 400, 500, and 600 are located in the Univ. The Core has a PhD level scientist as well as a specialist with a MS degree, and with more than 20 years of heme analysis experience, dedicated to complex assays needed to quantify iron, heme and the analysis of biosynthetic intermediates. The Drug Discovery Core (1300 sqf) is a centralized, staffed facility, and houses instrumentation and robotics required for high-throughput screening. We are also willing to facilitate data analysis from runs we generate. The award in his name recognizes a focused or singular achievement in fundamental or applied mass spectrometry in contrast to awards that recognize lifetime achievement. Phone: 801-587-7779 1,100 sq. This instrument is equipped with state-of-the-art tissue-imaging capability. The NCVS Training Institute employs three full-time psychologist lead trainers and five additional trainers. Facilities include a dark room, two fume hoods and a deoxygenation system. Porphyrin analysis, is performed with a Waters Acquity ultra-high pressure liquid chromatography (UPLC) system equipped with a reverse-phase C18 column and tandem high sensitivity photodiode array and fluorescence detectors, an HPLC Waters Alliance HT HPLC system. Facilities and Instrumentation and Services: The MGD core has all the necessary resources and equipment to carry out the molecular techniques required to accomplishtargeted gene editing and to identify animals or cells carrying the correct target genomic modification.

For basic mass spectrometry services such as accurate mass determination of small molecules, peptides and polymers, a number of instruments are employed for this including a Bruker Ultrafextreme MALDI-ToF, the Bruker Maxis II and an Agilent 6545 UPLC-QToF. Electron-capture dissociation (ECD) in the FTMS, Infrared multiphoton dissociation (IRMPD) in the FTMS, Collision-induced dissociation (CID) in the linear ion-trap, Demonstrate if unknown peptides contain cysteine or methionine (peptides <1000 MW), (e.g. Utah Nuclear Engineering Facility (UNEF) staff can assist in grant proposal development, experiment modeling, production of radioisotopes for experiment, measuring radioisotopes for biological studies, environmental sample analysis, elemental analysis, and sample sterilization. The ASMS Award for Distinguished Contribution in Mass Spectrometry is named to honor the memory of John B. Fenn who shared the 2002 Nobel Prize for the development of electrospray Ionization. The Core is staffed by a Director, James Cox, and two PhD level research associates, one dedicated to sample analysis, the other providing bioinformatics services. The NCVS is supported by faculty members who are principal investigators or co-investigators on several federal grants and contracts in excess of $10M, to include two DoD-funded randomized clinical trial currently underway at Fort Carson, Colorado, and a longitudinal health surveillance study with Air Force Special Operations Forces personnel. It is equipped with a nanoLC system (Eksigent) and is routinely used for protein ID from in-gel digests and protein ID from solution.

of Utah is a vested member (Sundquist and Davis groups) and owns 30% measurement time on the 800 and is guaranteed 10% share on the 900. Common EM procedures done in the lab include thin-sectioning, negative staining, metal shadowing (for scanning EM), cryogenic EM, immuno-EM, 2D image classification, and 3D image reconstruction (freestanding-particle and tomographic). The Facility is equipped with several high-performance mass spectrometers and accessory HPLC equipment. of Utah Health Sciences NMR Core Facility; measurement time is readily available on all instruments. A Hitachi H-7100 TEM (125 kV) is housed in the Radiobiology Laboratory Building, and another Hitachi H-7100 TEM is housed in the Biology Building. Recently installed at the MS Core Facility in Feb 2006, it is an extremely powerful instrument that is one of the highest-performance mass spectrometers in the world for proteomics research. While the emphasis of the facility is geared toward proteomics research, the facility continues to provide basic support for a broad range of research and sample types, such as natural products, small synthetic molecules, and large intact biopolymers. The Genomics Core Facility at the University of Utah provides a variety of cost-effective genotyping services to researchers on campus and around the world. Our areas of expertise include machine learning, deep learning (AI), medical computing, scientific visualization, data science, data analytics and data engineering. The Tecnai F20 is equipped with a Gatan K2 Summit direct electron detector. Software is available for advanced image analysis of cardiac mechanics with speckle tracking that allows analysis of strain and strain rate. The CZAR is a 5,600 sq. Additionally, the core has HP D300 Digital Dispenser which is capable of generating dose response curves which eliminates serial dilution by offering picoliter to microliter non-contact dispensing of small molecules in DMSO directly into assay plate. We offer the complete spectrum of cytometric solutions from consultation to report generation. MS/MS fragmentation techniques for peptide sequencing: Software for the LTQ-FT from ThermoElectron: Maldi/MS (positive or negative ion mode; linear or reflectron mode), Maldi/MS/MS (positive or negative; reflector mode), Low-energy LID fragmentation (in source laser fragmentation), Parent-ion mass isolation window about 1 to 3 Da, depending on mass, SmartLaser; 1000 Hz shot frequency; fast for tissue-imaging acquisitions, High resolution (10,000 to 30,000 resolution, depending on mass), Accurate mass measurements less than 5 ppm with internal standard calibration, Accurate mass measurements generally less than 20 ppm with external calibration, Femtomole-range sensitivity (e.g.

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